I find that if you have active hormonal acne, those big red and angry ones.. you can try this. It has a cotton swab for you that cleans the area before you place the patch on. I applied it on a new red acne, and it went down a little but for it go down I have to use it 2 night in a row. For sure, its faster than waiting for those acne to go off on its own, but this box only have 6 pieces it will only last 3 pimples. Despite the quantity, this product works and will recommend and repurchase.