I noticed my pimples clear faster when I used this because it sucks out the pus and clogged stuff from it rather than having to wait for the pimple to dry out and fall out (that is if you didn't pop it/squeeze it already). It starts to itch on my skin if I leave it on for over 24 hours. I think it's from whatever adhesive is on it. So it's best to give your skin some breathing time and reapply later.